周期门 (Ct) 值趋势在COVID-19:分析性别,年龄和严重性因素在印度主要浪潮
Rudra Kumar Pandey1, Vandana2, Shailesh Desai1
1Gyan Lab, Cytogenetics Unit, Department of Zoology, Banaras Hindu University, Varanasi, India.
Immunity, inflammation and disease
|February 25, 2026
概括
在COVID-19RT-PCR测试中的周期值 (Ct) 值因流行浪潮,年龄和性别而有显著差异. 较低的Ct值与较高的病毒载量和疾病严重程度相关,有助于公共卫生战略.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 实时聚合酶链反应 (RT-PCR) 对于COVID-19诊断至关重要.
- 周期值 (Ct) 值为病毒载量提供了洞察力.
研究的目的:
- 调查印度不同波段,年龄组和性别的COVID-19RT-PCRCT值的变化.
- 评估Ct值与病毒载量,疾病严重程度和流行病学指标的相关性.
主要方法:
- 对53,485例确诊的COVID-19病例进行了分析.
- 根据COVID-19波,年龄和性别对Ct值的分类.
- 应用非参数试验和线性回归用于关联分析.
主要成果:
- 在各波中观察到显著的Ct值变化,在波1中最高,在波2中最低.
- 儿童的Ct值最高;老年人的Ct值最低.
- 女性的Ct值低于男性;Ct值与病例/死亡之间存在负相关性.
结论:
- CT值作为病毒载量和疾病严重程度的预测标记.
- 监测Ct值可以增强疫情应对和资源分配策略.
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