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毛囊液中的17A型干白素和甲状腺自身抗体及其与卵巢反应的关系

Heba M Amr¹, Taghrid M Gaafar², Rehab El-Wakeel²

¹Galaa Assisted Reproduction Centre, Galaa Maternity Teaching Hospital, Cairo, Egypt.

American journal of reproductive immunology (New York, N.Y. : 1989)

|February 25, 2026

概括

介素-17A (IL-17) 和甲状腺自身抗体影响生育治疗. 升高的IL-17与高的卵巢反应有关,而两者都可能会在IVF期间损害低响应者的受精.

科学领域:

生殖内分泌学生殖内分泌学
免疫学免疫学免疫学
辅助生殖技术辅助生殖技术

背景情况:

介素-17A (IL-17) 和甲状腺自身免疫与不良的生殖结果有关.
在辅助生殖技术 (ART) 期间,IL-17和甲状腺蛋白自身抗体在卵巢卵泡环境中的特定作用尚不清楚.

研究的目的:

为了研究毛囊液 (FF) 中的介质素-17A (IL-17) 和铁血球蛋白自身抗体水平.
评估这些标记物与卵巢反应,受精率和胚胎学结果的关联,在接受细胞内注射精子-胚胎移植 (ICSI-ET) 的妇女中.

主要方法:

对87名接受ICSI的甲状腺功能良好的女性进行前性研究.
卵巢反应根据卵细胞产量被分类为低,亚最佳,正常或高.
通过ELISA在毛囊液中量化IL-17和甲状腺蛋白自身抗体.

主要成果:

在高响应者中观察到更高的IL-17水平,与MII和受精卵细胞相关.
在低响应者中,IL-17和甲状腺蛋白自身抗体与受精率有负相关性.
在年龄调整后,没有任何标志物在整体队列中预测临床怀孕.

结论:

升高的IL-17水平与ART的卵巢反应增强有关.
IL-17和铁血球蛋白自身抗体可能会对受精潜力产生负面影响,特别是在卵巢反应减弱的女性中.

关键词:

美国国务院调查局 (ICSI)在IL-17中,我们可以看到IL-17.毛囊液体毛囊液体毛囊液体卵巢反应的反应铁血球蛋白抗体铁血球蛋白抗体

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