产前头发皮质糖类水平与儿童行为问题之间的时间依赖关系
Richard G Künzel1,2, Yinxian Chen3, Marta B Rondon4,5
1Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Journal of child psychology and psychiatry, and allied disciplines
|February 25, 2026
概括
孕产妇产前压力,通过毛发皮质醇测量,与儿童的行为问题有关. 怀孕前更高的皮质激素预测了更多的问题,而怀孕早期更高的皮质激素预测了后代的更少问题.
科学领域:
- 神经内分泌学神经内分泌学
- 发展心理学 发展心理学
- 公共卫生 公共卫生
背景情况:
- 儿童内化和外化行为问题是全球重要的健康问题.
- 母亲产前压力是已知的危险因素,但神经内分泌路径尚不清楚.
研究的目的:
- 为了研究母毛皮质醇 (HCC) 和皮质素 (HCNC) 度与后代行为问题之间的关联.
- 探索产前压力生物标志物对儿童发育的时间依赖性影响.
主要方法:
- 在秘鲁利马的一项前性队列研究中,包括271个母婴双.
- 分析了母亲的头发样本 (怀孕前和头三个月),以检测HCC和HCNC.
- 儿童行为检查表评估后代的内部化和外部化问题,平均年龄为6.98岁.
主要成果:
- 怀孕前的头发皮质子度 (HCNC) 与后代内部化和外部化问题正相关.
- 第一季度的HCNC显示了与内部化和外部化问题的负面关联.
- 关联在雌性后代中更为明显,并没有观察到毛皮质醇 (HCC).
结论:
- 在产前头发皮质糖类水平和后代行为问题之间存在时间依赖的关联.
- 生物标志物数据的时间依赖建模对于理解跨代压力传播机制至关重要.
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