特定位点的氨酸乙化对tau与微管结合的作用:来自全原子分子动力学模拟的机理性见解

相关实验视频

Updated: Feb 26, 2026

Quantification of Site-specific Protein Lysine Acetylation and Succinylation Stoichiometry Using Data-independent Acquisition Mass Spectrometry
12:49

Quantification of Site-specific Protein Lysine Acetylation and Succinylation Stoichiometry Using Data-independent Acquisition Mass Spectrometry

Published on: April 4, 2018

12.1K

Pengxuan Xia1, Dushuo Feng1, Bote Qi1,2

  • 1Department of Sport and Exercise Science, College of Education, Zhejiang University, Hangzhou, Zhejiang, 310058, P. R. China. zouyuzy@zju.edu.cn.

Physical chemistry chemical physics : PCCP
|February 25, 2026
PubMed
概括

蛋白在特定部位 (K274,K280,K281) 的乙化削弱了它与微管细胞的结合. 这种对阿尔茨海默氏症等多病症的分子洞察力可以为新的治疗策略提供信息.

更多相关视频

A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli11:08

A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli

Published on: December 9, 2017

7.4K
Site Specific Lysine Acetylation of Histones for Nucleosome Reconstitution using Genetic Code Expansion in Escherichia coli07:26

Site Specific Lysine Acetylation of Histones for Nucleosome Reconstitution using Genetic Code Expansion in Escherichia coli

Published on: December 26, 2020

4.5K

相关概念视频

Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
5.7K
Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
15.4K