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在口腔状细胞癌手术期间顺序应用向性纳米剂的合理设计

Danni Shan¹, Diya Xie¹, Liping Zeng¹

¹Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing 210008, China. zywangkq@nju.edu.cn.

Biomaterials science

|February 25, 2026

概括

一种新的治疗纳米平台,AuNPs/HSA-ICG,通过结合手术前CT成像,手术内光指导和术后光动力学疗法 (PDT) 来提高口腔癌手术的精确边缘管理.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

口腔状细胞癌 (OSCC) 治疗严重依赖于彻底的手术切除,但目前的方法缺乏完整的工具来精确评估边际.
瘤边缘的可视化不足导致在管理残留癌症方面存在挑战,影响患者的治疗结果.

研究的目的:

开发和评价一个多功能光学纳米平台,用于OSCC的综合周术管理.
通过结合成像和治疗来提高手术精度和减少残留瘤负担.

主要方法:

开发一个纳米平台 (AuNPs/HSA-ICG),通过将绿色氨酸 (ICG) 和金色纳米粒子 (AuNPs) 装载到人血清白蛋白 (HSA) 上.
评估纳米平台在手术前CT成像,手术内近红外光指导和术后光动力疗法 (PDT) 的功能.
评估瘤向通过SPARC介导吸收和体内疗效在一个正管舌癌模型中的瘤向.

主要成果:

AuNPs/HSA-ICG纳米平台表现出稳定的光,强大的CT对比度和特定的瘤向.
结合CT和光成像精确地局部化瘤和视觉化手术边缘在一个orthotopic模型.
使用纳米平台的术后PDT有效地抑制了残留瘤模型中的再生.
安全评估表明生物相容性良好,系统毒性低.

结论:

开发的theranostic纳米平台为OSCC中精确的外科边缘管理提供了临床可转换的策略.
这种综合方法解决了当前术后护理的局限性,可能改善头癌的治疗结果.

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