人工大动脉门的计算流体动力学分析:倾斜植入对血液动力学的影响
Manuel Berger1, Jonna Golks1, Lena Gleissner1
1Department of Medical Technologies, MCI-The Entrepreneurial School, 6020 Innsbruck, Austria.
概括
选择正确的Medtronic Avalus门大小对于大动脉门更换至关重要. 25毫米的门可以改善血液流动并降低血栓形成风险,而27毫米的门可以增加血栓形成风险.
科学领域:
- 心血管工程 心血管工程
- 生物医学流体动力学
- 医疗器械设计 医疗器械设计
背景情况:
- 假肢-患者不匹配 (PPM) 和倾斜植入在大动脉置换 (AVR) 中可能会对血液动力学产生负面影响.
- 这些因素增加了壁切应力 (WSS) 和血栓形成的风险.
- 优化门选择对于成功的AVR结果至关重要.
研究的目的:
- 利用计算流体动力学 (CFD) 来分析不同大小的Medtronic Avalus心脏的血液动力学影响.
- 评估门大小对壁切应力 (WSS) 和血栓形成风险的影响.
- 为了确定最佳的门大小,以改善AVR患者的治疗结果.
主要方法:
- 使用Ansys Fluent对23毫米,25毫米和27毫米的Medtronic Avalus进行了CFD模拟.
- 模拟使用了生理边界条件,包括0.3m/s稳定的进气速度和无滑壁条件.
- 分析了墙壁剪切应力 (WSS) 和一般剪切应力 (SS),以评估血栓形成风险.
主要成果:
- 与23毫米相比,25毫米将WSS受影响面积减少20.83%,切削应力受影响面积减少7.64%.
- 27毫米将WSS受影响面积增加了41.25%,切削应力受影响面积增加了11.26%.
- 27毫米的门也显示了流和循环区域的升高,增加了血栓形成的风险.
结论:
- 适度扩大到25毫米的Medtronic Avalus可以提高AVR中的血液动力学性能.
- 进一步扩大到27毫米的门会导致压力和流的增加,从而增加血栓形成的风险.
- 最佳的门尺寸对于减轻有害的血液动力学影响和提高AVR安全性至关重要.
相关概念视频
Bernoulli's Principle
9.0K
Bernoulli's equation incorporates how fluid pressure changes across a static, incompressible fluid by equating the kinetic energy contribution to zero. It is also helpful in analyzing horizontal flows in which the gravitational energy density is constant throughout. The latter equation is so useful that it is called Bernoulli's principle. According to Bernoulli's principle, the fluid pressure drops if the speed increases and vice versa.
Bernoulli's principle has several...
Bernoulli's principle has several...
9.0K
Bernoulli's Equation for Flow Normal to a Streamline
1.2K
Bernoulli's equation for flow normal to a streamline explains how pressure varies across curved streamlines due to the outward centrifugal forces induced by the fluid's curvature. The pressure is higher on the inner side of the curve, near the center of curvature, and decreases outward to balance these centrifugal forces.
The pressure difference depends on the fluid's velocity and radius of curvature. The pressure variation is minimal in flows with nearly straight streamlines. However, the...
The pressure difference depends on the fluid's velocity and radius of curvature. The pressure variation is minimal in flows with nearly straight streamlines. However, the...
1.2K
Application of the Linear Momentum Equation
793
The application of the linear momentum equation can be used to analyze the forces needed to hold a 180-degree pipe bend in place with flowing water. In this case, water flows through the bend with a constant cross-sectional area of 0.01 square meters and a flow velocity of 15 meters per second. The pressure at the entrance is 0.2 Megapascals and the pressure at the exit is 0.16 Megapascals.
The goal is to determine the force components in the x and y directions to hold the pipe in place. Since...
The goal is to determine the force components in the x and y directions to hold the pipe in place. Since...
793
Velocity Potential
954
In steady, incompressible flow through a long, straight pipe with a uniform cross-section, the flow in the central region (far from the pipe walls) is irrotational. This irrotational nature means that fluid particles do not rotate around their axes, and a scalar function called the velocity potential, represented by ϕ, can be used to describe their movement. In irrotational flows, the velocity field V is defined as the gradient of the velocity potential:
954
Steady, Laminar Flow Between Parallel Plates
1.1K
Understanding steady, laminar flow between parallel plates is essential for analyzing and designing flow in narrow rectangular channels, commonly found in various water conveyance and drainage systems. The Navier-Stokes equations govern fluid motion and are generally challenging to solve due to their nonlinearity. However, simplifications are possible in certain cases, like the steady laminar flow between parallel plates. For this scenario, we assume steady, incompressible, laminar flow.
1.1K
Applications of Integration to Find Blood Flow
197
Blood flow through a cylindrical blood vessel can be mathematically described using the principles of laminar flow, a regime in which fluid moves smoothly in parallel layers. In this model, the velocity of the blood is not uniform across the cross-section of the vessel; rather, it varies with the radial distance from the center. The maximum velocity occurs along the central axis, decreasing progressively toward the vessel walls, where it reaches zero due to viscous drag.Approximating Blood...
197


