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Updated: Feb 26, 2026

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments

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可快速切换的双离子源结合ESI与iLTP/管等离子,用于LC-MS,多DLC×LC和SLIM-IM-MS应用

Marvin Häßler¹, Katharina Wetzel¹, Cedric Thom¹

¹Applied Analytical Chemistry, University of Duisburg-Essen, Universitätsstr. 5, 45141 Essen, Germany.

Journal of the American Society for Mass Spectrometry

|February 25, 2026

概括

一个新的双离子源使得电喷离子化 (ESI) 和介电屏障放电 (DBD) 等离子体之间的快速切换成为可能. 这一进步增强了高通量液体染色学-质谱分析,以提高实验室操作的效率.

科学领域:

分析化学分析化学
质谱测量质量谱测量
染色体学染色体学是一种染色学.

背景情况:

高通量分析对于高效和成本效益的实验室操作至关重要.
在液态染色体质谱法 (LC-MS) 中,尽量减少停机时间是一个关键的挑战.
不同的分析物电离行为需要灵活的分析方法.

研究的目的:

为LC-MS设计和建造一个双离子源.
为了使电子喷射电离 (ESI) 和介电屏障放电 (DBD) 等离子电离模式之间快速切换.
在高通量分析中评估双离子源的性能.

主要方法:

开发一种能够承受大气压ESI和DBD等离子电离的双离子源.
双离子源与单维和多维液态色谱的整合.
与四极飞行时间 (Q-TOF) 和离子移动性质谱 (IMS) 仪器的合.
混合标准和现实世界样本的分析.

主要成果:

双离子源在色谱运行过程中成功地实现了ESI和DBD电离模式之间的快速切换.
在整个电离模式切换过程中,保持了稳定的性能和强大的离子信号.
对于ESI和DBD电离,仪器检测极限低至1nM以下.
在一次运行中成功分析了具有不同电离性质的多种分析物.

结论:

开发的双离子源为高通量LC-MS分析提供了多功能解决方案.
它可以在单个分析工作流程中分析具有不同电离特性的化合物.
这项技术通过实现快速电离模式切换,提高了分析实验室的效率和成本效益.

关键词:

斯利姆 (Slim) 斯利姆 (Slim) 是一个小岛屿.在TPI上,TPI就是TPI.在 iLTPTP 里面.离子移动性的离子移动性质谱测量质谱测量质谱测量质谱测量质量测量质谱测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量基于等离子体的电离.

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