生物可访问的硫福拉减轻了肠道上皮细胞中氧化压力驱动的副炎症
Concepción Medrano-Padial1, Sonia Medina1, Cristina García-Viguera1
1Laboratorio de Fitoquímica y Alimentos Saludables (LabFAS), CSIC, CEBAS, Campus Universitario de Espinardo, Edificio 25, 30100 Murcia, Spain. smescudero@cebas.csic.es.
Food & function
|February 25, 2026
概括
花茎含有硫黄 (SFN),是一种抗炎化合物. 这项研究表明,西兰花茎中的SFN可以减少炎症和氧化应激,这表明健康促进产品的价值.
科学领域:
- 营养生物化学 营养生物化学
- 分子生物学分子生物学
- 食品科学 食品科学 食品科学
背景情况:
- 饮食中摄入富含硫 (SFN) 和葡萄糖的植物性食物,通过减轻炎症,为健康带来好处.
- 氧化应激和炎症与代谢疾病和衰老有关,强调需要有效的饮食干预措施.
研究的目的:
- 研究来自西兰花茎的可生物利用化合物的抗炎和抗氧化潜力.
- 为了确定从西兰花茎中提取的硫黄 (SFN) 是否可以预防与氧化应激相关的副炎症状况.
主要方法:
- 超高性能液体染色学-电子喷射电离-三重四极质谱学 (UHPLC-ESI-QqQ-MS/MS) 用于量化SFN.
- 在体外测试中评估了SFN对循环氧化酶-2 (COX-2),氧化应激标志物 (8-iso-PGF2α) 和炎症标志物 (PGF2α,PGE2) 的作用.
- 一个模型系统在不同SFN度下评估了COX-2表达和异质类化合物合成.
主要成果:
- 硫福拉 (SFN) 被确定为西兰花茎提取物生物可访问部分中唯一可量化的有机硫化合物.
- 通过降低COX-2,PGF2α和PGE2水平,SFN在体外显示出显著的抗炎能力.
- 尽管SFN具有较弱但显著的减轻氧化应激 (8-iso-PGF2α) 的能力.
结论:
- 花茎是一种有价值的生物可访问硫黄 (SFN) 的来源,具有显著的抗炎性质.
- SFN的抗炎作用部分独立于其抗氧化能力.
- 这些发现支持使用西兰花茎作为促进健康的副产品的成分,用于控制炎症和氧化应激.
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