糖尿病相关脚患者的认知障碍:一个多中心,病例控制,观察性研究
Nimantha Karunathilaka1,2,3, Peter Anthony Lazzarini1,4,5, Margaret MacAndrew1,2
1Centre for Healthcare Transformation, Queensland University of Technology, Brisbane, Queensland, Australia.
International wound journal
|February 25, 2026
概括
认知障碍与糖尿病相关的脚 (DFU) 有关. 即使有其他并发症,DFU也独立预测糖尿病和外围神经病变患者的认知得分较低.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 糖尿病学 糖尿病学
背景情况:
- 认知障碍是糖尿病的一个已知的并发症.
- 与糖尿病相关的脚 (DFU) 和认知功能之间的特定关联,独立于其他糖尿病并发症,如外围神经病变,仍然不清楚.
研究的目的:
- 研究2型糖尿病和外围神经病变患者的认知功能.
- 为了比较那些有活跃的DFU和那些没有DFU的人之间的认知分数.
主要方法:
- 一个年龄和性别匹配的多中心病例控制观察研究.
- 包括89名患有2型糖尿病和外围神经病变的参与者:49名患有DFU (病例) 和40名没有DFU (对照).
- 使用蒙特利尔认知评估 (MoCA) 工具评估全球认知.
主要成果:
- 与控制组相比,患有DFU的参与者具有明显较低的全球认知得分 (中位数[IQR] 24.0 [21.0-25.0]与26.0 [24.0-28.0];p < 0.001).
- 较低的全球认知独立地与DFU,外周动脉疾病,体力活动减少以及没有糖尿病家族史 (p ≤0.019) 的存在有关.
- 患有DFU的参与者具有与对照组相似的特征,除了较低的体重指数 (p = 0.028).
结论:
- 与糖尿病相关的足的存在与糖尿病患者和外围神经病变患者的认知障碍独立相关.
- 研究结果表明,DFU,不仅仅是其他糖尿病并发症,导致认知能力下降.
- 需要进一步的研究来探索因果机制,并开发针对DFU患者认知健康的有针对性的干预措施.
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