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在2021-22年期间,从印度尼西亚获得的鸟类传染性支气管炎病毒的完整基因组测序和植物遗传学分析

Heesu Lee^1,2, Pandya Pradipta Prajitno^3,2, Andrew Y Cho¹

¹Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Gwangjin-gu, Seoul, Republic of Korea, 05029.

|February 25, 2026

概括

这项研究对印尼传染性支气管炎病毒 (IBV) 的整个基因组进行了测序,揭示了GI-19血统菌株. 这些发现增强了对东南亚IBV流行病学的理解.

科学领域:

兽医病毒学兽医病毒学
鸟类健康鸟类健康
分子流行病学分子流行病学

背景情况:

传染性支气管炎病毒 (IBV) 在全球家禽行业造成重大经济损失,原因是呼吸道,脏和生殖系统问题.
目前在印度尼西亚流传的IBV菌株缺乏全面的数据.
了解本地IBV菌株对于有效的疾病控制和预防策略至关重要.

研究的目的:

在印度尼西亚分离的IBV菌株的整个基因组的特征.
为了确定这些印度尼西亚IBV菌株的遗传关系.
为了解东南亚IBV流行病学做出贡献.

主要方法:

来自印度尼西亚的六个IBV分离物的全基因组测序 (2021-22).
对尖尖糖蛋白S1亚单元编码序列的家族遗传学分析.
全基因组遗传学分析以调查遗传关系和重组.

主要成果:

根据S1基因测序,所有六种印尼IBV菌株都被归类为GI-19血统.
在S1编码序列中没有检测到重组的证据.
全基因组分析表明重组,但由于有限的数据库序列,原始体无法识别. 在马来西亚和泰国发现了最近的亲属.

结论:

这项研究提供了印度尼西亚IBV菌株的第一个全基因组序列.
这些发现强调了印尼存在GI-19血统IBV的存在,与邻国菌株有密切的遗传联系.
这项研究加深了对东南亚地区当前IBV流行病学的理解.

关键词:

印度尼西亚印度尼西亚印度尼西亚冠状病毒冠状病毒的新冠病毒.感染性支气管炎病毒感染性支气管炎病毒遗传学分析遗传学分析在家禽养殖场的家禽养殖场.进行全基因组测序.

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