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对患有混合表型急性白血病的儿童进行全源性造血干细胞移植:单中心回顾性研究

Wei Yang¹, Maoquan Qin, Chenguang Jia

¹Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Journal of pediatric hematology/oncology

|February 25, 2026

概括

全基性造血干细胞移植 (allo-HSCT) 为缓解期的儿科混合表型急性白血病 (MPAL) 患者提供了有利的结果. 与化疗相比,这种治疗显著改善了生存率和无事件生存率.

科学领域:

儿科血液学瘤学儿科血液学
造血干细胞移植造血干细胞移植
白血病研究研究白血病研究

背景情况:

混合表型急性白血病 (MPAL) 是儿童罕见且复杂的血液性恶性瘤.
在诊断和治疗方面,MPAL带来了挑战,需要有效的治疗策略.

研究的目的:

评估整体存活率 (OS),无事件存活率 (EFS) 和小儿MPAL中alo-HSCT的并发症.
为接受allo-HSCT的儿科MPAL患者提供治疗建议.

主要方法:

对接受allo-HSCT的14名儿科MPAL患者的回顾性分析.
收集的数据包括免疫表型,染色体异常,融合基因和移植细节.

主要成果:

在MRD阴性状态的CR1中观察到高OS (92.9%) 和EFS (85.7%) 的比率.
在Haplo-HSCT和MSD-HSCT之间没有显著的结果差异.
轻度慢性GVHD是常见的 (71.4%),皮肤参与是最常见的.

结论:

在MRD阴性CR中,alo-HSCT为儿科MPAL提供了有利的疾病控制.
与传统化疗相比,Allo-HSCT显著改善了OS,EFS和CIR率.
轻度慢性GVHD没有显著影响日常活动.

关键词:

造血干细胞移植造血干细胞移植混合的表型急性白血病.治疗疗法治疗疗法治疗疗法与移植相关的并发症

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