胆囊切除术后肠道微生物群失生症与不良临床结果之间的关联:一个单一中心的回顾性病例对照研究
Zhenhong Li1, Fang Zhang2, Xiaoyi Sun3
1Clinical Laboratory, Ezhou Maternal and Child Health Hospital, Ezhou City, China.
The American surgeon
|February 25, 2026
概括
胆囊切除术后肠道微生物群失生症很常见,增加了腹和代谢问题的风险. 识别这些不平衡可以帮助管理症状,并针对肠肝轴干预措施.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 代谢健康 代谢健康
背景情况:
- 肠道微生物群的改变会影响胃肠道和代谢健康.
- 胆囊切除术后失生症的临床意义尚不清楚.
研究的目的:
- 调查肠道微生物群失调症在胆囊切除术后出现持续症状的患者中的患病率和临床影响.
- 为了确定与术后胃肠道和代谢障碍相关的特定微生物变化.
主要方法:
- 75名接受胆囊切除术 (2020-2023) 的成年患者进行了回顾性病例对照研究,并呈现出持续的症状.
- 进行了便微生物群测试,并使用评分系统将患者分为失生症或生症组.
- 基线特征,微生物概况和结果的比较,与相关性和多变量回归分析.
主要成果:
- 失生症组显示有益细菌 (例如,Bifidobacterium,Lactobacillus) 的减少和有害细菌 (例如,大肠杆菌,C. perfringens) 的增加,以及Firmicutes-to-Bacteroidetes比率的升高.
- 在失生症组中观察到较低的α多样性 (Shannon,Chao1指数).
- 功能失调与腹增加,腹部张张和ALT水平升高相关. 米与细菌的比率与ALT正相关,而Bifidobacterium与甘油三相反相关.
- 失生症是术后腹的一个独立风险因素 (调整后OR=2.87).
结论:
- 肠道微生物群失生症是在胆囊切除术后经常发现的.
- 功能失调与术后腹和代谢变化的更高发病率有关.
- 微生物群简介可以帮助风险分层,并指导针对肠肝轴的治疗策略.
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