光物理引导的升级转换纳米系统用于传感.
Yuxia Liu1,2, Jiaye Chen1, Xiaogang Liu1,2,3,4
1Department of Chemistry, National University of Singapore, Singapore 117549, Singapore.
Accounts of chemical research
|February 25, 2026
概括
光子向上转换纳米粒子将近红外光转换为更高的能量,使先进的生物感知成为可能. 最近的材料和光学工程提高了成像,诊断和治疗中的应用效率.
科学领域:
- 光物理和材料科学 材料科学
- 纳米技术和生物传感技术
- 生物医学工程 生物医学工程
背景情况:
- 光子上升转换 (UC) 将低能近红外光转换为更高能发射,提供最小的自发光和深层组织透等优势.
- 兰化物杂的纳米粒子是关键的UC系统,但在安全辐射极限下,在体内应用中量子产量很低.
- 核心架构和表面工程已经显著提高了UC纳米粒子的效率,稳定性和生物相容性.
研究的目的:
- 审查最近在将上转化纳米粒子 (UCNPs) 与生物传感和生物接口的各种物理模式相集成方面的进展.
- 突出提高UC效率和信号保真性的策略.
- 探索超越传统发光的UCNP应用,包括电气,机械和热读取.
主要方法:
- 总结光子向上转换的光物理原理.
- 详细介绍材料设计策略,如核心外架构和表面修改.
- 审查UCNP与光学显微镜,电生理学,光遗传学和其他物理传感方式的整合.
主要成果:
- UCNP 能够长期追踪单个粒子,超高分辨率成像和实时监测生物过程.
- 基于UCNP的系统可促进非侵入性神经调节,亚细胞温度计和先进的成像技术.
- 与设备集成允许随机编码,红外视觉和生物相容接口.
结论:
- 上转化纳米粒子是强大的光学激发和生物反应接口,在生物传感和生物接口中具有广泛的应用.
- 进一步提高量子产量,降低激发功率和建立生物安全性对于临床转化至关重要.
- 像人工智能引导的设计和与再生医学的整合等新兴方向有望克服当前的挑战并扩大UCNP的潜力.
相关概念视频
01:23Photoluminescence: Fluorescence and Phosphorescence
4.1K
Photoluminescence is a process where a molecule absorbs light energy and re-emits it in the form of light. This phenomenon occurs when a substance absorbs photons, promoting its electrons to higher energy level excited states, followed by a relaxation process in which the electrons return to their original ground state energy levels and emit light. Photoluminescence is widely observed in various materials, including semiconductors, and organic and inorganic compounds.
A pair of electrons in a...
A pair of electrons in a...
4.1K
01:14Photoluminescence: Applications
1.2K
Photoluminescence offers a wide range of applications due to its inherent sensitivity and selectivity. This technique allows for both direct and indirect analyses of the analyte. Direct quantitative analysis is possible when the analyte exhibits a favorable quantum yield for fluorescence or phosphorescence. However, an indirect analysis may be feasible if the analyte is not fluorescent or phosphorescent, or if the quantum yield is unfavorable. Indirect methods include reacting the analyte with...
1.2K