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Updated: Jul 4, 2026

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons
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用皮质脊髓运动神经元丰富的皮质器官模拟性4揭示了基因型-表型和HDAC6-向性病理

Neha Mohan1, Skandha Ramakrishnan1, Xiaohuan Sun1

  • 1Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA.

Cell reports
|February 25, 2026
PubMed
概括

性4 (SPG4) 涉及影响运动神经元的基因突变. 抑制基因素脱乙酶6 (HDAC6) 恢复了神经元功能,改善了模型中的步态,揭示了潜在的治疗点.

关键词:
在CP:神经科学.CP:干细胞研究.这就是SPASTAST.皮质有机物 皮质有机物皮层脊髓运动神经元基因组脱乙酶6 基因组脱乙酶6人类诱导的多能干细胞干细胞.微微管中的乙化.性截肢症 4 性截肢症 4在斯巴斯蒂纳,我们吃了斯巴斯蒂纳.图巴斯丁A是一种

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