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准备好或不准备好,他们来了:为医疗瘤学家的固体瘤采用T细胞治疗的实用指南

Tuan Hoang^1,2, Sameena Khan^1,3, Adrian Sacher^1,4

¹Division of Medical Oncology & Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

|February 25, 2026

概括

采用细胞疗法 (ACT) 在固体瘤中表现有前途,为癌症治疗提供了一个新的范式. 早期识别和管理毒性,如细胞因子释放综合征 (CRS) 和神经毒性 (ICANS),对于患者的成功至关重要.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.

背景情况:

采用细胞疗法 (ACT) 已经彻底改变了血液恶性瘤治疗.
新出现的数据突出显示了ACT在固体瘤中的潜力,标志着癌症治疗的重大转变.

研究的目的:

审查目前关于实体瘤中ACT的临床数据.
概述CRS和ICANS的主要发现,毒性概况和管理策略.

主要方法:

对实体瘤的ACT最近临床试验数据的综合.
审查已建立和新兴的毒性概况,重点关注CRS和ICANS.
对免疫相关毒性早期识别和管理协议的基于证据的概述.

主要成果:

在治疗固体瘤方面,ACT显示出显著的潜力,具有有前途的临床试验结果.
细胞因子释放综合征 (CRS) 和免疫效应细胞相关的神经毒性综合征 (ICANS) 是需要谨慎管理的关键毒性.
对CRS和ICANS的有效管理策略对于优化患者的治疗结果至关重要.

结论:

在实体瘤瘤学中,ACT代表着一个范式的转变.
医疗瘤学家必须准备好管理与ACT相关的独特毒性.
优化患者的治疗结果需要全面了解ACT及其相关毒性,包括CRS和ICANS.

关键词:

收养细胞疗法采用细胞疗法.双特异性T细胞参与者 (BiTE)在CAR-T细胞中.免疫效应细胞相关的神经毒性综合征 (ICANS)细胞因子释放综合征 (CRS)固体瘤是一种固体瘤.

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