早期停止癌症治疗的成本影响:现实世界的数据分析
H C Post1,2,3, K Opmeer4, T Schutte5,6
1Amsterdam UMC location University of Amsterdam, Department of Oncology, ; Meibergdreef 9, Amsterdam, the Netherlands.
The oncologist
|February 25, 2026
概括
近30%的高成本的癌症治疗被提前停止,耗资数百万美元. 了解早期停止治疗 (ETD) 是提高癌症护理效率和患者结果的关键.
科学领域:
- 在瘤学瘤学.
- 卫生经济学 卫生经济学
- 药物经济学 药物经济学
背景情况:
- 由于癌症发病率的增加和高成本的抗癌药物,医疗保健支出不断增加.
- 早期停止治疗 (ETD) 既存在效率低下,也存在临床合理的决定,但国家数据有限.
- 荷兰在管理与抗癌药物使用相关的成本方面面临挑战.
研究的目的:
- 量化荷兰高预算抗癌药物的早期治疗中止 (ETD) 率.
- 评估2018年至2022年这些药物的ETD相关成本.
- 分析ETD的趋势及其在五年内对经济的影响.
主要方法:
- 来自荷兰国家索赔数据库的现实数据的回顾性分析.
- ETD的定义是治疗开始后90天内停止治疗.
- 专注于2022年影响最大预算的前30种抗癌药物.
主要成果:
- 在2022年,ETD占这些抗癌药物的7.83亿欧元支出中的9.9% (7.7亿欧元).
- 在30343次治疗中,有29.7%的治疗在90天内停止.
- 从2018年到2022年,药物总成本增加了27.1%,而ETD成本增加了9.6%,具体药物之间存在显著差异.
结论:
- 大约30%的抗癌治疗被提前停止,这对整体药物成本作出了重大贡献.
- ETD包括潜在的低效率和必要的临床决策.
- 优化患者选择和治疗策略对于合理和公平地使用昂贵的癌症疗法至关重要.
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