随着时间的变化,监测eosinophilic食道炎缓解的内镜,以及与治疗结果的关系
Sean S LaFata1, Timothy S Gee1, Cary C Cotton1
1Department of Medicine, Center for Esophageal Diseases and Swallowing and Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, NC USA.
概括
对于缓解期的性食道炎 (EoE) 的最佳监测内镜时间尚不清楚. 较长的间隔 (>2年) 在数值上显示出较少的组织学反应和更多的症状,这表明较短的监测可能对EoE患者有益.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 性食道炎 (EOE) 需要在患者实现缓解时进行持续监测.
- 在EoE缓解中监测内镜的最佳时间尚未确定.
研究的目的:
- 在EOE患者实现组织学缓解后,评估监测内镜的时间变化.
- 调查监测时间和EoE疾病结果之间的关联.
主要方法:
- 稳定治疗91名EoE患者的组织学缓解 (<15eos/hpf) 的回顾性队列研究.
- 分析第一个监测内镜后缓解的时间,分类为间隔 (≤1年,1-2年,>2年).
- 监测间隔间临床病理特征和疾病结果的比较.
主要成果:
- 在监测内镜检查后的时间 (平均1.3年) 中观察到显著的变化.
- 缓解时更大的扩张大小与更长的监测间隔相关 (R=0.36,p=0.03).
- 与较短的间隔相比,监测>2年的患者数量较少的患者保持了组织学反应 (59%) 并报告了更多的症状 (47%).
结论:
- 在EoE缓解中,监测时间有很大差异,并受到扩张大小的影响.
- 虽然结果在间隔之间相似,但更长的监测间隔 (>2年) 显示出减少组织学反应和增加症状的趋势.
- 需要进一步的研究,以确定最佳的监测内镜时间来缓解EoE.
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