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Updated: Feb 27, 2026

Generation of Genomic Deletions in Mammalian Cell Lines via CRISPR/Cas9
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Generation of Genomic Deletions in Mammalian Cell Lines via CRISPR/Cas9

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序列保留蛋白质缺失的PON-Del预测器

Haoyang Zhang1, Muhammad Kabir1, Mauno Vihinen1

  • 1Department of Experimental Medical Science, Lund University, Lund, Sweden.

PLoS computational biology
|February 25, 2026
PubMed
概括

我们创建了PON-Del,这是一个新的工具,可以预测不改变下游序列的蛋白质删除. 它准确地分类变异,包括不确定的变异,改进了现有的遗传变异解释方法.

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Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
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