RNA.

Albéric A de Lajarte1, Yves J Martin des Taillades2, Justin Aruda1

  • 1Department of Microbiology, Harvard Medical School, Boston, MA, USA.

Science advances
|February 25, 2026
PubMed
概括

研究人员开发了eFold,这是一种用于RNA二级结构预测的深度学习模型. 这种在各种化学探测数据上训练的模型通过结合结构复杂性,而不仅仅是数据库大小,提高了预测准确性.

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Overview
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The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
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