世界结核病增长因素:ASCO指南更新
Bishal Gyawali1, Kari Bohlke2, Jana K Dickter3
1Queen's University, Kingston, ON, Canada.
概括
血液形成殖民地刺激因子 (CSF) 建议癌症患者在化疗风险高时预防发烧性中性质衰竭. 此外,CSF还有助于干细胞动员,并更新了关于其使用和选择的指导方针.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 支持性护理是一种支持性护理.
背景情况:
- 中性衰竭事件和发烧性中性衰竭是接受化疗的癌症患者的重大风险.
- 造血殖民地刺激因子 (CSF) 在管理这些风险和干细胞动员中至关重要.
研究的目的:
- 提供美国临床瘤学会 (ASCO) 关于在成人癌症患者中使用CSF的最新指南.
- 纳入关于CSF,生物类似药和相关药物的新证据,用于预防中性质衰竭和干细胞调动.
主要方法:
- 进行了随机对照试验 (RCT),元分析和系统审查的系统审查.
- 文献搜索涵盖了PubMed和Cochrane图书馆的文章,这些文章于2014年9月1日至2025年8月22日之间发表.
- 一个ASCO专家小组审查了证据,制定了最新的建议.
主要成果:
- 该审查包括33项RCT和16项系统性审查.
- 新的CSF,额外的生物类似药和干细胞调动的CXCR4抑制剂被确定为证据库的补充.
- 有证据支持使用CSF用于发烧性中性质的特定风险值和干细胞调动.
结论:
- 预防性CSF推用于化疗,发烧性中性质的风险大约为20%或更高.
- 如果患者具有高风险特征,可能需要进行首要的CSF预防治疗,以低于20%的风险进行化疗.
- 单独或与CXCR4抑制剂结合,CSF对干细胞动员是有效的;提供了有关剂量和选择的最新指导.
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