动态吸烟模式和帕金森病风险和全因死亡率:一种竞争风险分析方法
Sung-Ho Ahn1, Duk Ho Kim2, Jimin Park3
1Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Neurology
|February 25, 2026
概括
戒烟,即使是暂时的,也可能增加帕金森病 (PD) 的风险,但持续戒烟会降低死亡率. 目前的吸烟状态,而不是累积暴露,似乎与PD风险有关.
科学领域:
- 流行病学 流行病学
- 神经退行性疾病 神经退行性疾病
- 公共卫生 公共卫生
背景情况:
- 吸烟与帕金森病 (PD) 相反相关,但可能会因过早死亡而引起混.
- 由于吸烟行为的动态,戒烟对PD风险和死亡率的长期影响仍然不清楚.
研究的目的:
- 调查吸烟状态的纵向变化与PD风险和全因死亡率之间的关联.
- 使用竞争性风险框架和基于年龄的时间尺度,以左截断进行分析.
主要方法:
- 对410,489名40岁以上吸烟的韩国成年人的回顾性队列研究.
- 参与者被分为持续吸烟者,最近戒烟者,持续戒烟者和复发吸烟者,根据三个检查期的吸烟状况进行分类.
- 使用精细灰色模型估计的PD累积发病率函数与所有原因死亡率作为竞争事件.
主要成果:
- 持续吸烟者患PD风险最低.
- 与持续吸烟者相比,最近和持续戒烟的人的PD风险较高 (sHR为1.60-1.61).
- 持续戒烟者 (17%) 和最近戒烟者 (3%) 的全因死亡率低于持续吸烟者.
结论:
- 患PD的风险似乎与目前的吸烟状况有关,而不是累积暴露.
- 短期戒烟 (∼2年) 并没有否定与PD的保护性关联.
- 持续戒烟提供死亡率的好处,支持早期戒烟.
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