大麻素受体2激活抗体:对于巨驱动的纤维炎性疾病来说,这是一个有前途的治疗策略
Raghavender Reddy Gopireddy1, Dipankar Bhattacharya2, Swastik Sen1
1Abalone Bio, Inc., Emeryville, California.
Molecular pharmacology
|February 25, 2026
概括
新的CB2激素抗体,AB120和AB150,表现出强大的抗炎和抗纤维作用. 这些第一类抗体向巨细胞激活,为由慢性炎症驱动的纤维性疾病提供了有前途的新疗法.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
背景情况:
- 纤维性疾病是由慢性炎症和巨细胞激活驱动的.
- 目前的小分子CB2激动剂在特异性和药物特性方面存在局限性.
- 开发GPCR激素抗体具有独特的挑战.
研究的目的:
- 开发和表征新的CB2特异性激素抗体.
- 评估这些抗体的抗炎和抗纤维的潜力.
- 为了证明GPCR抗体激动剂的治疗前景.
主要方法:
- 开发出第一类的CB2激素抗体 (AB120,AB150).
- 对抗体特异性和G蛋白偏差的评估.
- 在实验室测试巨细胞激活标记物和细胞因子表达 (IL-6,IL-1β,TNF-α).
- 在精密切割的人类肝脏切片上进行炎症和原表达的ex vivo测试.
主要成果:
- AB120和AB150是CB2特定的,G-α偏差的.
- 抗体有效地降低了巨细胞激活标记物和促炎细胞因子.
- 活体治疗减少了肝脏切片中的炎症标志物和原表达.
结论:
- 新型CB2激素抗体显示出显著的抗炎和抗纤维素潜力.
- 这些抗体为纤维化和炎症性疾病提供了有前途的治疗策略.
- GPCR抗体激动剂代表了针对具有挑战性的受体的可行方法.
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