对加速表观遗传衰老的个性和认知性
Yannick Stephan1, Angelina R Sutin2, Martina Luchetti2
1Euromov, Univ. Montpellier, Montpellier, France.
Journal of psychiatric research
|February 25, 2026
概括
良心和开放等人格特质促进了对加速表观遗传衰老的认知性,而神经病则与较低的性有关. 这突出了个性.
科学领域:
- 老年学和认知神经科学
- 表观遗传学和衰老研究研究.
背景情况:
- 人格特征与对抗痴呆症神经病理学的认知性有关.
- 加速表观遗传衰老是生物衰老和认知衰退的标志物.
研究的目的:
- 调查人格特征与对加速表观遗传衰老的认知性之间的关联.
- 为了确定个性是否影响相对于生物衰老标志物的认知功能.
主要方法:
- 利用来自健康和退休研究 (HRS) 的2926名成年人 (50-98岁) 的数据.
- 评估人格,认知和表观遗传衰老 (GrimAge,DunedinPoAM38) 的情况.
- 认知性定义为对表观遗传衰老措施回归的认知残留.
主要成果:
- 较高的神经性与相对于表观遗传年龄的比预期更差的认知相关.
- 更高的认真和开放与比预期更好的认知有关.
- 神经病症预测认知性较低,而良心和开放性预测了更高的性.
结论:
- 人格特征与对加速表观遗传衰老的认知性有显著的关联.
- 这些关联在考虑各种健康和生活方式因素后仍然存在.
- 这些发现将弹性研究扩展到神经病理学之外,包括系统衰老影响.
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