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休息状态功能磁共振成像在帕金森病深度大脑刺激期间的测试-重新测试可靠性

Skyler Deutsch¹, Juhi Mehta¹, Lee B Reid¹

¹Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, USA.

NeuroImage. Clinical

|February 25, 2026

概括

使用功能磁共振成像 (fMRI) 进行深度大脑刺激 (DBS) 可能是不可靠的. 主动刺激和金属工件影响fMRI的可靠性,影响其用于帕金森病的研究和治疗.

科学领域:

神经成像是一种神经成像.
神经调节是一种神经调节.
医疗器械医疗器械

背景情况:

功能磁共振成像 (fMRI) 越来越多地用于研究深度大脑刺激 (DBS).
了解fMRI可靠性对于解释数据和优化DBS治疗至关重要.
现代DBS硬件允许患者接受fMRI扫描.

研究的目的:

评估fMRI脑连接和可变度指标在同时进行深度脑刺激 (DBS) 的可靠性.
调查活性刺激和设备金属工件对fMRI可靠性的影响.
确定影响帕金森病患者fMRI可靠性的受试者之间的变化因素.

主要方法:

16名帕金森病患者的亚thalamic核或形DBS接受了3T测试-重新测试休息状态fMRI.
为了评估可靠性,fMRI与并发DBS进行或不进行.
分析了刺激,金属工件和运动对fMRI指标的影响.

主要成果:

大脑变异性fMRI指标显示的可靠性 (ICC 0.36-0.85) 比连接性指标 (ICC 0.68-0.99) 高.
网络连接在 DBS ON 和 OFF 之间是不那么可重现的.
在受金属文物影响的区域,fMRI可靠性有所不同,大脑变异性可靠性更高,连接性更低.

结论:

深度脑刺激 (DBS) 硬件和活跃刺激可以改变fMRI可靠性.
报告单一研究fMRI可靠性对于开发临床生物标志物至关重要.
需要进一步的研究来建立可重复的fMRI评估DBS研究.

关键词:

深度大脑刺激是什么?功能性磁共振成像技术功能性磁共振成像技术金属工艺品的金属工艺品这是一个开源的开源软件.帕金森病是帕金森病的一种.测试-重新测试可靠性可靠性

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