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喘患者的牙脸缺陷和唾液生物标志物:一个范围审查
Shailaja Raghavan1, Elham S Abu Alhaija1, Abeer A Almashraqi1
1College of Dental Medicine, QU Health, Qatar University, Doha, Qatar.
喘与牙科问题有关,如后部交叉咬伤和改变的唾液生物标志物,包括IL-6和VEGF. 需要进一步的研究来证实这些关联.
科学领域:
- 口腔健康 口腔健康
- 呼吸系统医学 呼吸系统医学
- 生物标志物研究 生物标志物研究
背景情况:
- 喘是一种慢性呼吸道疾病,具有潜在的全身影响.
- 牙面部缺陷和唾液生物标志物越来越被认为是相关的健康指标.
研究的目的:
- 审查有关喘,牙面部缺陷和唾液生物标志物之间的联系的现有证据.
- 识别这个跨学科领域的知识缺口和未来的研究方向.
主要方法:
- 按照乔安娜·布里格斯研究所和PRISMA-ScR指南进行系统的文献搜索.
- 包括2000年至2025年8月期间发表的病例控制和横截面研究.
- 对评估喘与缺陷或唾液生物标志物相关的研究进行分析.
主要成果:
- 九项研究将喘与背部交叉咬伤,前部开口咬伤和关节间宽度减少等缺陷联系起来.
- 十三项研究发现液中介质素-6 (IL-6) 和血管内皮生长因子 (VEGF) 在喘患者中升高.
- 对于其他生物标志物如IL-8,埃索诺菲尔酸蛋白,α氨酶和IL-1β.观察到可变的结果.
结论:
- 有限的证据表明喘与特定的dentofacial malocclusions之间存在联系.
- 某些唾液生物标志物的水平变化与喘有关,尽管研究结果并不总是一致的.
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