卡普托普利可调节暴露在高海拔和寒冷压力下的肉中的血管活性和氧化途径
Behnam Ahmadipour1, Hediyeh Sheykh1, Hossein Hassanpour2
1Department of Animal Sciences, Faculty of Agriculture, Shahrekord University, Shahrekord, Iran.
Poultry science
|February 25, 2026
概括
饮食中补充卡波普利尔有效地减轻肉的高海拔和寒冷压力. 这改善了肉的生长,降低了炎的死亡率,并通过抑制血管酶转化酶 (ACE) 来增强心肺健康.
科学领域:
- 动物科学动物科学
- 身体生理学 身体生理学
- 环境压力生物学
背景情况:
- 高海拔低氧和寒冷压力会对肉生产产生负面影响.
- 这些压力诱导氧化应激和血管活性失衡通过renin-angiotensin系统 (RAS).
- 了解缓解策略对于改善肉福利和生产率至关重要.
研究的目的:
- 为了研究食卡普托普利的疗效,一个血管酶转化酶 (ACE) 抑制剂,在抵消高海拔和寒冷压力在 brojlers.
- 评估卡普托普里尔对生长性能,尸体产量,心肺健康,氧化应激标志物和相关基因表达的影响.
主要方法:
- 240只肉在寒冷压力下,在2100米的海拔上食了0,10,20或30毫克/公斤的卡波普里尔.
- 评估的参数包括生长表现,尸体特征,死率,肺高血压综合征 (PHS) 指数 (RV:TV比),血液标志物 (ACE,NO,MDA,H:L比) 和肺基因表达 (eNOS, iNOS,ET1,SOD1,GPX).
主要成果:
- 卡普托普利在20-30毫克/公斤的剂量改善了料转化,尸体产量,并降低了炎死亡率和PHS指数.
- 在接受卡波普里尔治疗的组中,观察到ACE活性和MDA显著降低,NO水平增加.
- 基因表达分析显示,抗氧化剂和氧化合成基因 (eNOS,iNOS,SOD1,GPX) 的上调和内甲蛋白-1 (ET1) 的下调.
结论:
- 食卡波普里尔 (20-30毫克/公斤) 有效地改善肉的高海拔和寒冷压力.
- 卡普托普里尔通过抑制ACE,增强抗氧化防御,减少氧化应激和炎症来改善肉生产.
- 卡普托普里尔补充剂在具有挑战性的环境条件下对肉心肺健康和整体表现产生积极影响.
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