卵巢卵泡中的铁代谢不良:在子宫内膜异位症中对卵细胞质量和胚胎发育的影响
Yu Xiang1, Yang Zhang1, Xia Wang1
1Reproduction Medicine Centre, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.
Reproductive biomedicine online
|February 25, 2026
概括
子宫内膜异位症与铁过载和铁死有关,在IVF/ICSI期间对卵细胞和胚胎质量产生负面影响. 准铁代谢可能会改善这些患者的生育结果.
科学领域:
- 生殖生物学 生殖生物学
- 细胞病理学 细胞病理学
- 不孕症的研究研究.
背景情况:
- 子宫内膜异位症与不孕症有关,但影响卵细胞和胚胎质量的潜在机制尚未完全理解.
- 铁代谢和ferroptosis,一个调节的细胞死亡途径,涉及到各种细胞功能障碍.
研究的目的:
- 研究铁代谢和铁亡对卵细胞和胚胎质量的影响,在接受体外受精/细胞内精子注射 (IVF/ICSI) 的子宫内膜异位症患者中.
- 在人类患者和小鼠模型中探索这些效应.
主要方法:
- 在57名子宫内膜异位症患者和153名对照患者之间比较了胚胎学结果和卵泡液标记物 (铁,氧化应激).
- 在颗粒细胞中评估与铁亡相关的蛋白质表达.
- 使用了人类颗粒细胞和小鼠卵细胞/胚胎模型,暴露在铁过载和铁灭调节器中.
主要成果:
- 患有子宫内膜异位症的患者卵细胞成熟和胚胎质量较差,卵泡液中铁和氧化应激标志物增加.
- 在小鼠模型中,铁过载诱导了颗粒细胞中的铁亡,减少了卵细胞成熟,并损害了线粒体功能.
- 在细胞和动物模型中,ferrostatin-1 (fer-1) 治疗逆转了这些有害影响.
结论:
- 子宫内膜异位症患者的毛囊表现出铁过载和脂质过氧化,导致卵细胞和胚胎质量下降.
- 这些发现阐明了与子宫内膜异位症相关的不孕症的病理生理学.
- 向铁代谢和铁亡是一种潜在的治疗策略,可以提高IVF/ICSI接受子宫内膜异位症患者的生育结果.
更多相关视频
11:29Surgical Techniques to Optimize Ovarian Reserve during Laparoscopic Cystectomy for Ovarian Endometrioma
Published on: January 22, 2022
15.7K
06:40Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization
Published on: October 24, 2025
1.0K
相关概念视频
Oogenesis
70.6K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
70.6K
Oogenesis
4.4K
Oogenesis, the process of developing egg cells (female gametes), occurs within the ovaries and is fundamental to female fertility. This sequence begins during fetal development when diploid oogonia in the developing ovaries undergo mitotic divisions to produce primary oocytes. By birth, these primary oocytes enter prophase I of meiosis but become arrested in this stage, remaining suspended until puberty.
Each primary oocyte is surrounded by a layer of pre-granulosa cells, forming what is...
Each primary oocyte is surrounded by a layer of pre-granulosa cells, forming what is...
4.4K
Infertility in Females
4.9K
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
4.9K
Ovarian Cycle
4.6K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
4.6K
Hormonal Regulation of the Menstrual Cycle
1.9K
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
1.9K
