横截面分析表明,身体脂肪分布与多发性硬化症出院患者的基于表现和自我报告的结果无关
Ariel Kidwell-Chandler1, Brenda Jeng1, Robert W Motl1
1Department of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois Chicago, Chicago, IL, USA.
Multiple sclerosis and related disorders
|February 25, 2026
概括
在这项研究中,身体脂肪分布与多发性硬化症 (MS) 结果没有显著相关. 虽然关节脂肪与抑郁症和生活质量有联系,但需要进一步研究.
科学领域:
- 神经学 神经学
- 代谢健康 代谢健康
- 身体组成分析 身体成分分析
背景情况:
- 肥胖是多发性硬化症 (MS) 的已知因素,但关于身体脂肪对MS结果的影响的证据是不一致的.
- 身体脂肪的分布,特别是脂肪组织的位置,对于MS可能比总体脂肪更重要.
研究的目的:
- 调查双能X射线吸收计 (DXA) 测量的身体脂肪分布指标是否与基于表现和自我报告的MS结果相关.
- 探索内脏和皮下脂肪组织,安卓/肌肉脂肪质量和MS相关的功能和心理措施之间的关系.
主要方法:
- 57名患有多发性硬化症的门诊成年人使用DXA来评估身体脂肪的分布.
- 评估结果包括身体功能测试 (定时起床和起床,定时25英尺步行,六分钟步行) 和自我报告的措施 (焦虑,抑郁,MS影响,疲劳,疼痛).
- 斯皮尔曼相关性被用来分析关联,控制性别和年龄.
主要成果:
- 身体脂肪分布指标与多发性硬化症结局之间的大多数相关性都很弱,在统计学上并不显著.
- 膝关节%脂肪质量与抑郁症状 (HADS-D) 和与身体健康相关的生活质量 (MSIS物理) 有显著的相关性.
- 然而,这些相关性在控制性别和年龄时失去了统计学意义 (部分相关性).
结论:
- 该研究没有发现身体脂肪分布和通常研究的MS相关结果之间的显著关联.
- 这些发现表明,脂肪,包括其分布,可能在MS相关的结果中起到有限的作用,这与一些先前的假设相反.
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