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选择性单个胚胎转移在体外受精周期中,使用下一代测序进行或不进行植入前遗传测试:一种随机临床试验

Pedro Felipe Magalhães Peregrino¹, Carlos Augusto Z Nissel¹, Patricia Florido¹

¹Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas da Faculdade de Medicina da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.

Clinics (Sao Paulo, Brazil)

|February 25, 2026

概括

使用下一代测序 (NGS) 的植入前遗传检测 (PGT-A) 不能改善单个胚胎移植的IVF预后良好患者的怀孕率. 这项研究发现,胚胎遗传分析在这个患者群体中没有显著的益处.

科学领域:

生殖医学生殖医学
遗传学是一个遗传学.
在体外受精 (IVF)

背景情况:

在试管婴儿中,用于胚胎选择,越来越多地使用了预植入性形性遗传检测 (PGT-A).
它在良好的预后患者的临床实用性是有争议的,对使用下一代测序 (NGS) 的好处的PGT-A的证据有限.
缺乏关于PGT-A (NGS) 对预后良好,接受选择性单胚胎移植 (eSET) 的试管婴儿患者怀孕和活产率的影响的可靠数据.

研究的目的:

为了比较具有良好的预后的试管婴儿患者的临床怀孕率,这些患者接受了带有或没有PGT-A (NGS) 的eSET.

主要方法:

一项前性随机临床研究,涉及206名患者.
患者被随机分为两个组:没有遗传分析的eSET (SET组,n=103) 和使用NGS的PGT-A的eSET (NGS + SET组,n=103).
主要终点是第一个胚胎移植后的临床怀孕率.

主要成果:

第一次转移后的临床怀孕率在SET组 (76.7%) 和NGS+SET组 (79.6%) (p=0.613) 之间是相似的.
两组之间没有观察到活产率或堕胎率的统计学上显著差异.
该研究发现,在这个患者群体中,PGT-A (NGS) 治疗结果没有改善.

结论:

PGT-A (NGS) 没有显著改善受精不孕夫妇的试管婴儿结果,这些夫妇有良好的预后,接受了eSET.
在预后良好的试管婴儿患者中,PGT-A (NGS) 的临床实用性仍然值得怀疑.
可能需要进一步的研究来确定可能受益于PGT-A.的特定子组.

关键词:

在试管婴儿受精体外受精.这是下一代测序.植入前遗传诊断植入前遗传诊断生殖医学是一种生殖医学.单个胚胎移植妊娠率单个胚胎移植妊娠率

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