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Updated: Feb 28, 2026

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
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开发4'-化的核酸原药,以提高耐受性

Austin T Ryan1, Jean-Marc I A Lawrence1, Brett Virgin-Downey1

  • 1Emory Institute for Drug Development (EIDD), Emory University, Atlanta, GA, 30322, USA.

European journal of medicinal chemistry
|February 25, 2026
PubMed
概括

研究人员开发了一种新的前药物,EIDD-3639,由4'-尿素 (4'-FlU) 衍生,以提高口服抗病毒疗效和耐受性. 这种优化的抗病毒药物在治疗流感和其他病毒感染方面表现有前途,并减少了副作用.

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