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Updated: Feb 28, 2026

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O-GlcNAc转移酶通过调节线粒体呼吸链复合体I的活性来调节卵细胞成熟

Zhiming Ding1, Caiyun Wu1, Xuanxi Li1

  • 1Department of Obstetrics and Gynecology, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, No 218 Jixi Road, Hefei 230022, Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University),Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Key Laboratory of Reproductive Disorders and Obstetrics and Gynaecology Diseases, No 218 Jixi Road, Hefei 230022, Anhui, China; Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China; Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei 230032, Anhui, China.

Free radical biology & medicine
|February 25, 2026
PubMed
概括

O-GlcNAc转移酶 (OGT) 对于女性生育至关重要. 卵细胞中OGT缺乏会损害卵细胞的成熟,并通过破坏线粒体功能和螺旋组装检查点导致不孕症.

关键词:
这是一种O-GlcNAcylation.其他 OGT 产品.卵子细胞是卵子细胞.介质变化 (meiosis) 是一种变质的过程.线粒体功能 线粒体功能

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