Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Proteomics01:33

Proteomics

10.0K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
10.0K
Ribosome Profiling02:24

Ribosome Profiling

4.2K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
4.2K
Protein Networks02:26

Protein Networks

4.6K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

HBV-driven expansion of CXCR6<sup>+</sup>-exhausted T cells and CXCL16<sup>+</sup> macrophage interaction: Implications for immunotherapy in HCC.

Innovation (Cambridge (Mass.))·2026
Same author

The ASH HematOmics Program supports integrative analysis of genomic and clinical data in hematologic diseases.

Blood·2026
Same author

Cell type-dependent suppression of the RNA helicase DDX3Y levels by the close paralog DDX3X.

Frontiers in cell and developmental biology·2026
Same author

A systematic study of molecular diagnosis, treatment, and prognosis in infant-type hemispheric glioma: An individual patient data meta-analysis of 164 patients.

Neuro-oncology·2025
Same author

The Medulloblastoma Meta-Analysis Portal Enables Integrative Exploration of Clinical and Genomic Data from Patients.

Cancer research·2025
Same author

An integrated analysis of three medulloblastoma clinical trials refines risk-stratification approaches for reducing toxicity and improving survival.

Neuro-oncology·2025

相关实验视频

Updated: Feb 28, 2026

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
07:28

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

3.7K

综合性蛋白转录组学方法揭示了新的ADAM9基质和下游途径.

Congyu Lu1, Xiaolu Xu2, Neha Sindhu1

  • 1Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA; Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19713, USA.

Molecular & cellular proteomics : MCP
|February 25, 2026
PubMed
概括

这项研究确定了金属蛋白酶ADAM9的标,揭示了它在mTOR和FOXO等关键癌症途径中的作用. 这项工作为ADAM9提供了新的见解.

关键词:
在ADAM9中,ADAM9是ADAM9的前身.生态主区的脱落.福克斯OFOXO 在线播放在mTOROR中使用.蛋白质转录基因组学

更多相关视频

Author Spotlight: Cost-Effective Transcriptomic Drug Screening - Unlocking New Targets
06:40

Author Spotlight: Cost-Effective Transcriptomic Drug Screening - Unlocking New Targets

Published on: February 23, 2024

1.8K
Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

12.8K

相关实验视频

Last Updated: Feb 28, 2026

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
07:28

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

3.7K
Author Spotlight: Cost-Effective Transcriptomic Drug Screening - Unlocking New Targets
06:40

Author Spotlight: Cost-Effective Transcriptomic Drug Screening - Unlocking New Targets

Published on: February 23, 2024

1.8K
Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

12.8K

科学领域:

  • 生物化学 生物化学
  • 分子生物学分子生物学
  • 蛋白质组学是指蛋白质组学.

背景情况:

  • ADAM9是一种细胞表面金属蛋白酶,参与了ectodomain脱落.
  • 失调的ADAM9活性与包括癌症,自身免疫和COVID-19在内的疾病有关.
  • 了解ADAM9基质对于阐明它在健康和疾病中的作用至关重要.

研究的目的:

  • 系统地识别ADAM9.9的转录和后转录标.
  • 为了发现由ADAM9.9调节的信号通路.
  • 为了确定ADAM9.9的直接和间接基质.

主要方法:

  • 综合性蛋白质转录组学方法.
  • 使用具有稳定双胞胎型的HCT116细胞进行奥米克分析.
  • 对ADAM9目标的系统识别.

主要成果:

  • 确定了ADAM9下游的主要信号通道,包括mTOR和FOXO通道.
  • 没有覆盖的ADAM9的直接和间接基板.
  • 提供了对ADAM9功能的机制性见解.

结论:

  • ADAM9 调节关键的致癌 (mTOR) 和瘤抑制 (FOXO) 途径.
  • 确定了介导ADAM9病理生理学作用的新基质.
  • 开发了一种可转移的方法来研究膜蛋白酶.