在青少年精神病医院住院患者中隐含情绪处理的有效连接性:跨双相情感障碍和其他精神病理学的动态因果建模
Renata Rozovsky1, Halimah Abdul-Waalee2, Mariah Chobany2
1Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA; Department of Biomedical Informatics,University of Pittsburgh, Pittsburgh, PA, USA.
Journal of affective disorders
|February 25, 2026
概括
儿科双相情感障碍 (BD) 涉及改变处理社会情绪的大脑连接,影响面部暗示识别. 了解这些神经差异可以帮助早期诊断和干预青少年患有BD.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发展心理学 发展心理学
背景情况:
- 儿科双极性障碍 (BD) 诊断是具有挑战性的,因为症状与其他精神疾病重叠,可能延迟关键干预.
- 识别用于识别隐性面部情绪线索的客观神经标记可以显著改善儿科BD的早期诊断.
研究的目的:
- 使用动态因果建模 (DCM) 调查有效连接 (EC) 模式,以区分儿科双相情感障碍 (BD) 与其他精神病理 (OP) 和健康对照 (HC).
- 探索已识别的EC模式与青少年住院患者的临床症状严重程度之间的关联.
主要方法:
- 通过神经成像和DCM分析了BD (n=29),OP (n=39) 和HC (n=21) 的青少年在情感面部处理任务期间的EC.
- 参数实证贝叶斯 (PEB) 分析检查了EC模式,随后进行了与临床症状严重程度的相关性分析.
主要成果:
- 在各组和情绪状况中观察到不同的和融合的EC模式.
- 儿科BD和OP组的有效连接与自我报告的躁狂,抑郁和影响的临床症状显著相关.
结论:
- 社会情绪处理和执行控制区域之间的EC变化可能解释了儿科BD中隐性面部情绪处理的困难.
- 这些功能障碍的神经连接模式可能是BD年轻人观察到的社会障碍的基础.
- 了解这些神经变化为有针对性的干预提供了潜在的机会,以改善儿科BD的社会功能.
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