马中的肺纤维化与自发的Crotalaria juncea中毒有关
Andrezza C Andrade1, Silvio M C Fonseca1, Givaldo B Silva Filho1
1Laboratório de Diagnóstico Animal, Universidade Federal Rural de Pernambuco (UFRPE), Rua Dom Manuel de Medeiros s/n, Recife, PE 52171-900, Brazil.
Toxicon : official journal of the International Society on Toxinology
|February 25, 2026
概括
在巴西马匹中,Crotalaria juncea中毒导致严重的肺损伤和体重减轻. 该研究确定了该植物是导致这种马类中毒爆发的原因.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 毒理学 毒理学 毒理学
- 马的健康 马的健康
背景情况:
- (Crotalaria juncea) 是一种已知具有有毒性质的植物.
- 被C. juncea中毒会导致牲畜出现严重的健康问题.
- 马的呼吸困扰和体重减轻是需要调查的严重临床症状.
研究的目的:
- 为了调查巴西东北部马群中一种无法解释的疾病的爆发.
- 在受影响的马匹中识别逐渐减肥和呼吸困难的致病原体.
- 描述与马类中毒相关的病理发现.
主要方法:
- 受影响马的临床病例报告.
- 马体解剖和马体组织病理学检查.
- 牧场对潜在的有毒植物暴露的环境评估.
主要成果:
- 马匹呈现逐渐减肥和严重的呼吸困难.
- 尸体解剖显示了广泛的肺间歇性纤维化,支气管增生和肺动脉重塑.
- 观察到肝脏中枢球核亡,可能是低氧的次要原因.
- 在马的牧场中证实了大量的C. juncea植物入侵.
结论:
- 克罗塔拉里亚冬中毒是观察到的马匹疫情的可能原因.
- 病理发现表明严重,慢性肺损伤与植物诱导的毒性相一致.
- 管理策略应侧重于从马牧场清除C. juncea,以防止未来的中毒.
相关概念视频
01:17Other Pulmonary Disorders
1.8K
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
1.8K
01:17Pulmonary Cycle: Exhalation
4.2K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
4.2K