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怀孕期间与早期儿童神经发育有关的孕产妇炎症和氧化应激

Seonyoung Park¹, Deborah J Watkins¹, Sung Kyun Park²

¹Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA.

Brain, behavior, and immunity

|February 25, 2026

概括

怀孕期间的孕产妇炎症和氧化应激与儿童神经发育不佳有关,特别是在男性中. 这些影响因妊娠时间和儿童年龄而异,突出了关键的发育窗口.

科学领域:

神经科学是一个神经科学.
发展生物学发展生物学
环境健康环境健康

背景情况:

胎儿大脑发育在怀孕期间对母亲的健康非常敏感.
由炎症和氧化应激驱动的母体免疫激活可能会对后代的神经发育产生负面影响.
关于母亲炎症,氧化应激和儿童神经发育的流行病学数据有限.

研究的目的:

调查怀孕期间母亲的炎症和氧化应激以及儿童早期神经发育之间的关联.
探索孩子的性别,年龄和妊娠时间的潜在修改.

主要方法:

使用了来自PROTECT出生队列 (波多黎各) 的数据.
在怀孕期间测量了母体血清炎症生物标志物和尿路氧化应激标志物.
评估儿童神经发育使用Battelle发育清单-2西班牙版 (BDI-2) 在1-3岁之间.
采用线性混合效果模型,调整混因素并探索效果修改.

主要成果:

孕产妇炎症生物标志物与BDI-2结果有多种关联,例如,MMP1与较低的适应性得分相关.
观察到性别特异性影响,男性的负面关联通常更强.
孕产妇的氧化压力 (IsoP) 与男孩的适应能力和个人社会分数较低有关.
关联因妊娠时间 (在怀孕后期更强) 和儿童年龄 (在年长儿童中更强) 而有所不同.

结论:

孕期炎症和氧化压力可能会对早期神经发育产生不利影响.
关联可能会因妊娠时间,孩子的年龄和孩子的性别而改变.
进一步的研究应该检查这些因素在应对产前压力因素时的调解作用.

关键词:

炎症炎症是一种炎症.神经发育神经发育氧化应激是一种氧化应激.怀孕怀孕怀孕怀孕

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