用Withania somnifera进行激素调节:随机对照试验的系统审查和元分析
Michal Fornalik1, Anna Malkiewicz1, Dominika Adamczak2,3
1Faculty of Medicine, Poznan University of Medical Sciences, Poznan, Poland.
Planta medica
|February 25, 2026
概括
在男性中,阿什瓦甘达补充剂显著影响激素水平,降低皮质醇,增加血清素和. 由于研究异质性,需要进一步的研究.
科学领域:
- 内分泌学 在内分泌学.
- 神经内分泌学神经内分泌学
- 草药研究 草药研究
背景情况:
- 与压力,不孕症和代谢问题相关的荷尔蒙失衡.
- 阿什瓦甘达 (Withania somnifera L.) 是一种适应原体,有建议的内分泌调节作用.
研究的目的:
- 系统地审查口服阿什瓦甘达对成人激素水平的影响的随机对照试验.
- 评估阿什瓦甘达对下丘脑-垂体-上腺和淋巴腺轴的影响.
主要方法:
- 在 MEDLINE,Embase,ClinicalTrials.gov 搜索; 在 PROSPERO.gov 注册.
- 包括23个随机的,安慰剂控制的试验 (1706名参与者).
- 使用随机效应模型进行元分析;评估偏见和异质性.
主要成果:
- 阿什瓦甘达降低了皮质醇 (SMD -1.18) 和增加了血清素 (MD 31.75 ng/ml).
- T4的适度增加 (MD 0.61μg/dL);对TSH或T3没有影响.
- 男性的丸激素增加 (MD 57.43 ng/dl),但女性没有;对E2.2没有影响.
结论:
- 口服阿什瓦甘达补充剂调节关键的激素通路,包括皮质醇和性激素.
- 观察到的潜在的剂量反应影响基于withanolide含量.
- 由于异质性和有限的数据,进一步的标准化试验是有必要的.
更多相关视频
04:59Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia
Published on: May 30, 2025
1.8K
08:15Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
Published on: June 6, 2025
675
相关概念视频
01:19Management of Insomnia
740
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
740
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
699
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
699
01:33Hormonal Regulation
36.5K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
36.5K
01:40Hormonal Regulation
49.0K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
49.0K
01:23Sedatives and Hypnotics: Overview
1.7K
Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
1.7K
01:26Anxiolytic Drugs: Overview
1.3K
Anxiolytic drugs are vital in managing anxiety disorders by effectively alleviating symptoms such as excessive fear, tachycardia, and tremors. There are several classes of anxiolytic medications, each with unique mechanisms of action and potential side effects.
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic...
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic...
1.3K