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Updated: Feb 28, 2026

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ACTN3基因型与肌肉功能的关联:系统性审查和元分析
Mika Kamiya-Saito1, Hirofumi Zempo2, Kathleen Yasmin de Almeida3
1Research Institute for Sport Science, Nippon Sport Science University, Tokyo, Japan.
International journal of sports medicine
|February 25, 2026
概括
ACTN3 R577X基因变异与肌肉强度和功率有关. 具有RR,RX和XX基因型的个体表现出更高的一次重复最大,最大自愿收缩和跳跃性能.
科学领域:
- 遗传学和体育科学 遗传学和体育科学
- 人体生理学 人体生理学
- 分子生物学分子生物学
背景情况:
- ACTN3基因R577X多态影响α-actinin-3的表达,α-actinin-3是一种对肌肉功能至关重要的蛋白质.
- 以前的研究表明,ACTN3基因型和运动表现之间存在联系,特别是在力量和力量方面.
研究的目的:
- 系统地审查和元分析ACTN3 R577X多态和肌肉强度和功率指标之间的关联.
- 为了澄清肌肉性能变化的遗传基础.
主要方法:
- 在PubMed和Web of Science的系统文献搜索到2025年10月15日.
- 纳入标准:英语出版物,健康参与者,评估肌肉功能,以及ACTN3 R577X基因型分析.
- 53篇文章的元分析,检查了结果,如一次重复的最大值,跳跃性能和最大自愿收缩.
主要成果:
- 在添加模型中,在ACTN3 R577X多态和一次重复最大,最大自愿收缩和跳跃性能之间发现了显著的关联.
- 在这些指标中,RR,RX和XX基因型的表现更高 (p < 0.01).
- 对于其他测试的肌肉功能的测量,没有发现任何显著的关联.
结论:
- ACTN3 R577X多态性与肌肉强度和功率的关键指标有关,特别是一次重复的最大,最大自愿收缩和跳跃性能.
- 对这些绩效指标的遗传影响在男性中可能更为明显.
- 这一发现有助于理解运动潜力的遗传基础.
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