相关实验视频

Updated: Feb 28, 2026

Identification of Novel CK2 Kinase Substrates Using a Versatile Biochemical Approach
11:11

Identification of Novel CK2 Kinase Substrates Using a Versatile Biochemical Approach

Published on: February 21, 2019

7.9K

来自缺乏CaMKIIα和CaMKIIβ的小鼠皮质组织的蛋白组分析确定了新的体外基质

Pomme M F Rigter1,2, Karel Bezstarosti3, Oguz Can Koc4

  • 1Department of Clinical Genetics, Erasmus MC, 3015 GD Rotterdam, The Netherlands.

ACS chemical neuroscience
|February 25, 2026
PubMed
概括

/卡尔莫杜林依赖蛋白激酶II (CaMKII) 对于大脑功能至关重要. 这项研究确定了新的CaMKII基质和酸化部位,揭示了它在大脑中的重要作用的新见解.

关键词:
在CaMKII基质共识序列的共识序列.卡姆克2a/卡姆克2b双重淘汰赛/卡尔莫杜林依赖蛋白激酶II型α和β (CaMKIIα和CaMKIIβ)皮层 皮层 皮层在体内活体基质.光蛋白质组学 光蛋白质组学 光蛋白质组学

更多相关视频

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

19.4K
Visualizing Protein Kinase A Activity In Head-fixed Behaving Mice Using In Vivo Two-photon Fluorescence Lifetime Imaging Microscopy10:41

Visualizing Protein Kinase A Activity In Head-fixed Behaving Mice Using In Vivo Two-photon Fluorescence Lifetime Imaging Microscopy

Published on: June 7, 2019

9.1K

相关概念视频

cAMP-dependent Protein Kinase Pathways01:25

cAMP-dependent Protein Kinase Pathways

Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...
8.7K
Calmodulin-dependent Signaling01:16

Calmodulin-dependent Signaling

Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
6.7K