感染可以导致脆弱吗? 来自巴尔的摩长度老龄化研究的见解
Francesco Saverio Ragusa1, Toshiko Tanaka2, Michael R Duggan3
1Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, 90127, Italy.
概括
感染病史可能会加速老年人虚弱的进展. 这种增加的脆弱性,结合感染史,独立地提高死亡风险,而瘦素表明肥胖症.
科学领域:
- 老年学是指老年学的学科.
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 脆弱的老年人面临更高的感染风险.
- 感染史,脆弱性和死亡率之间的联系需要进一步调查.
研究的目的:
- 调查感染史,脆弱性和全因死亡率之间的关联.
- 探索感染史和脆弱性在预测死亡风险方面的共存.
主要方法:
- 利用了来自1399名参与者 (平均年龄为65.3岁) 的巴尔的摩长度衰老研究 (BLSA) 的数据.
- 感染史由ICD-9代码确定;使用44项脆弱指数 (FI) 评估脆弱性.
- 用多重线性回归和考克斯的比例危险模型来分析关联.
主要成果:
- 感染史,包括尿路感染和肺炎等特定类型,与更高的FI相关 (p ≤0.01).
- 血瘦素和BMI调解了感染史和脆弱性之间的关系.
- 感染史和高FI (≥0.12) 的参与者显示死亡风险明显增加 (HR 1.12,p=0.02).
结论:
- 感染史可能会加快虚弱的进展,独立地或与虚弱相结合地增加死亡风险.
- 莱普的调解作用表明肥胖在感染-脆弱性关系中的参与.
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