通过利用第二代RRM2和CHK1抑制剂的协同潜力,针对神经母细胞瘤中的复制应激

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Iris H Nelen1,2, Soetkin Leys1,2, Sarah-Lee Bekaert1,2

  • 1Pediatric Precision Oncology Lab (PPOL), Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.

Cell death & disease
|February 25, 2026
PubMed
概括

将RRM2抑制与CHK1抑制剂相结合显示出治疗神经母细胞瘤和肉瘤的前景. 这种新的方法针对复制应激,增强癌细胞死亡,并显示出显著的治疗潜力.

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