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Updated: Feb 28, 2026

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Martin Garrido-Rodriguez1,2,3,4, Clement Potel1, Mira Lea Burtscher1

  • 1Molecular Systems Biology unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.

Nature communications
|February 25, 2026
PubMed
概括

这项研究重新审视了使用蛋白质组学和酶基质数据的经典信号通路. 我们发现了许多尚未探索的相互作用,突出了当前途径观点的局限性,并提出了新的研究假设.

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Protein Kinases and Phosphatases

Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
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Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
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