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Updated: Feb 28, 2026

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter
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Published on: March 31, 2022

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ERCC6L2确保了对分阶段的DNA双链断裂的修复保真性

Eric J Aird1, Almudena Serrano-Benitez2,3, Sebastian M Siegner1

  • 1Department of Biology, Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.

Nature communications
|February 25, 2026
PubMed
概括

蛋白质ERCC6L2保护细胞免受由分层DNA断裂引起的DNA损伤,这对于基因组编辑的准确性至关重要. 它的缺失导致基因组不稳定性和对DNA损伤剂的敏感性增加.

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