珊瑚微生物组作为未知的基因组和生物合成多样性的储存库
Fabienne Wiederkehr1, Lucas Paoli2,3, Daniel Richter4,5
1Department of Biology, Institute of Microbiology and Swiss Institute of Bioinformatics, ETH Zürich, Zürich, Switzerland.
Nature
|February 25, 2026
概括
珊瑚礁拥有巨大的微生物生物合成潜力,对发现新药非常重要. 保护这些重要的生态系统对于保护这种分子多样性及其潜在益处至关重要.
科学领域:
- 海洋微生物学 海洋微生物学
- 生物多样性研究的研究.
- 自然产品的发现自然产品的发现.
背景情况:
- 珊瑚礁是重要的海洋生物多样性热点,提供必要的生态系统服务.
- 与珊瑚礁无脊椎动物相关的微生物是生物活性代谢物的重要来源.
- 珊瑚礁构建珊瑚,珊瑚礁结构的关键,在很大程度上未经评估的微生物生物合成潜力.
研究的目的:
- 系统地评估珊瑚礁构建珊瑚的微生物编码生物合成潜力.
- 评估珊瑚微生物组中存在的分子资源.
- 强调珊瑚礁保护对生物多样性的重要性.
主要方法:
- 从太平洋的820个珊瑚礁构建样本中对微生物群落的基因组分析 (塔拉太平洋探险队).
- 将已识别的微生物物种及其基因组信息的可用性与现有数据库进行比较.
- 对珊瑚微生物组的生物合成潜力的评估与已知的天然产品来源相比.
主要成果:
- 在塔拉太平洋样本中,只有不到1%的专门识别的微生物物种具有可用的基因组信息.
- 珊瑚礁构建珊瑚微生物组的生物合成潜力与海绵的生物合成潜力相当或超过.
- 在珊瑚礁微生物群中发现了具有新型酶学的新型酸菌群.
结论:
- 珊瑚礁构建的珊瑚微生物组代表了一个丰富的,在很大程度上未被开发的新型分子多样性的来源.
- 保护珊瑚礁对于保护这些独特的微生物资源至关重要.
- 鉴定的新型酶学为未来的功能性蛋白质工程应用提供了潜力.
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