OMICmAge通过将多omics与电子医疗记录集成来量化生物年龄
Qingwen Chen1,2, Varun B Dwaraka3, Natàlia Carreras-Gallo3
1Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Nature aging
|February 25, 2026
概括
研究人员使用临床数据开发了EMRAge,这是一种新的死亡风险生物标志物. 这种衰老生物标志物DNAmEMRAge显示出与慢性疾病和死亡率的强烈关联,提供了可扩展的健康测量尺度.
科学领域:
- 生物遗传学 生物遗传学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 生物标志物开发 生物标志物开发
背景情况:
- 生物衰老是一个复杂的过程,可以通过欧米层测量.
- 现有的衰老和死亡风险生物标志物在可访问性和可扩展性方面存在局限性.
- 电子医疗记录为开发新的健康指标提供了丰富的数据来源.
研究的目的:
- 开发和验证EMRAge,一种来自常规临床数据的新型死亡风险生物标志物.
- 探索DNA甲基化和多组数据在完善生物年龄估计中的实用性.
- 为广泛的临床应用建立一个可扩展和可访问的生物衰老指标.
主要方法:
- 在约31,000名来自Mass General Brigham生物库参与者的常规临床实验室数据上利用弹性净回归来开发EMRAge.
- 使用DNA甲基化 (DNAmEMRAge) 和多omics数据 (OMICmAge) 建模的EMRAge.
- 在发现和多重验证队列中验证了DNAmEMRAge和OMICmAge对事件/流行慢性疾病和死亡率的性能.
主要成果:
- EMRAge,DNAmEMRAge和OMICmAge与慢性疾病和死亡率有很强的关联.
- 这些新型生物标志物在大型,多样化的队列中表现与现有生物标志物相比或优于它们.
- OMICmAge成功地集成了蛋白质组,代谢组和临床数据,使用了单独从DNA甲基化中量化的表观遗传生物标记代理.
结论:
- 开发的EMRAge框架提供了一个可访问和可扩展的生物衰老测量方法.
- DNAmEMRAge 和 OMICmAge 提供了关于疾病风险和死亡率的可靠预测.
- 这种方法有可能揭示影响健康和疾病易感性的分子联系.
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