在没有产品温度传感器的情况下,获得初级干燥模型的传热系数 (Kv) 的实惠和简单的新方法
C A Amor1,2, A Nardi-Ricart3, J R Ticó1
1Department of Pharmacy and Pharmaceutical Technology, and Physical Chemistry, Unit of Pharmaceutical Technology, Universitat de Barcelona, Av. Joan XXIII, 27-31, 08028, Barcelona, Spain.
AAPS PharmSciTech
|February 25, 2026
概括
一种新的重力测量方法可以在没有直接产品温度传感器的情况下确定传热系数 (Kv). 这种技术提供了一种更简单,更实惠的方法来测量冷干燥应用中的Kv值.
科学领域:
- 制药工程 制药工程
- 化学工程是化学工程的重要组成部分.
- 材料科学 材料科学 材料科学
背景情况:
- 精确测量传热系数 (Kv) 对于优化冷干燥工艺至关重要.
- 传统的重力测量方法通常依赖于直接测量产品温度,这在复杂或大规模的设置中可能具有挑战性.
- 在冷干燥机内的传感器放置和可访问性存在局限性,阻碍了全面的数据采集.
研究的目的:
- 引入一种新的,无传感器的方法来确定传热系数 (Kv) 值.
- 将"重力测量法"作为传统重力测量技术的替代方案.
- 证明新方法对各种容器类型的适用性和优势.
主要方法:
- 该研究描述了一种用于确定Kv值的新型重力测量方法.
- 升华前面的温度是间接地通过人称压力读数测量.
- 一个具有量身定制算法的初级干燥模型被用于计算Kv值.
主要成果:
- 在不需要产品温度传感器的情况下,重力度法成功获得了Kv值.
- 确定了Kv值,用于冷干燥不钢杯子和嵌套瓶子在不同的压力.
- 新方法与传统的重力测量方法进行了比较,显示了可比的结果.
结论:
- 重力度法为获得KV值提供了一种经济实惠且简单的程序.
- 这种技术克服了离散产品温度传感器的局限性,使KV能够确定整个批量.
- 这种方法对于具有挑战性传感器可访问性的应用特别有利,例如大型批量冷干燥机.
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