皮层刺激性映射将精神分裂症的神经生物学亚型分层化,具有遗传和分子特征

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Updated: Feb 28, 2026

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Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms

Published on: November 1, 2019

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Sixuan Guo^1,2, Yu Zhao¹, Xiao Ji^1,3

¹Department of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, Psychoradiology Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China.

BMC medicine

|February 26, 2026

概括

皮层刺激性映射在第一次发作患者中发现了两种不同的精神分裂症 (SCZ) 亚型. 这些亚型显示出不同的大脑变化和临床轨迹,为精确精神病学铺平了道路.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
计算生物学计算生物学

背景情况:

精神分裂症 (SCZ) 呈现出显著的异质性,使诊断和治疗复杂化.
目前的分类在变化和低稳定性方面扎.
神经刺激-抑制 (E-I) 平衡的破坏与SCZ症状有关.

研究的目的:

调查皮层刺激性 (CE) 地图是否可以揭示SCZ.的生物学上有意义的亚型.
描述前未使用药物的第一期SCZ (FES) 患者中EI失调的空间模式.
将CE亚型与临床轨迹和分子机制联系起来.

主要方法:

对77名FES患者和76名健康对照 (HC) 进行了CE映射.
通过voxel-wise比较识别了CE异常,并将患者分为子类型.
进行了纵向临床评估,并将CE数据与转录和神经受体数据集成.

主要成果:

与HC患者相比,FES患者在额叶,感觉运动皮质和右皮中表现出CE异常.
出现了两种亚型:FES1具有广泛的CE减少和更大的症状负担;FES2具有保存的CE和较轻的症状.
转录组分析将FES1与突触功能障碍,FES2与多系统参与联系起来.

结论:

基于CE的亚型有效地捕捉了临床和生物相关的SCZ异质性.
这种方法将神经电路功能障碍与分子签名相结合.
在SCZ中,CE亚型为推进精密精神病学提供了一个有前途的框架.

关键词:

皮层刺激性皮层刺激性第一个情节精神分裂症.神经生物学子类型神经生物学子类型神经递质受体的个人资料神经递质受体的个人资料心理辐射学心理辐射学转录的签名转录的签名

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