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Updated: Feb 28, 2026

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人类抗菌因子APOL3结合了线粒体DNA排泄和I型IFN诱导的溶酶体损伤

Dominic A Ritacco1, Hamna Shahnawaz1, Antonia Oduguwa1

  • 1Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.

Molecular cell
|February 26, 2026
PubMed
概括

溶酶体损伤通过释放线粒体DNA (mtDNA) 触发免疫反应. 二型干扰素 (IFN-γ) 启动细胞使用抗菌蛋白APOL3,增强mtDNA释放和I型干扰素的产生.

关键词:
它们是DNA DNA DNA DNA.伤害的伤害的伤害的伤害.这是先天的免疫力.干扰子干扰子干扰子细胞内细菌是细胞内细菌.lysosome 溶解酶体是如何形成的这是线粒体的线粒体.病毒病毒病毒病毒.

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