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Updated: Feb 28, 2026

Characterization of Neuronal Lysosome Interactome with Proximity Labeling Proteomics
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Characterization of Neuronal Lysosome Interactome with Proximity Labeling Proteomics

Published on: June 23, 2022

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解锁"不可抗药":目前的景观和新兴的边界在 lysosomal受体介导的蛋白质降解中

Yi-Meng Ma1, Hou-Fu Xia1,2, Yi-Lei Xiao3

  • 1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, People's Republic of China.

Drug delivery
|February 26, 2026
PubMed
概括

lysosome-targeting chimeras (LYTACs) 提供了一种新的方法来降解细胞外和膜蛋白,扩大向蛋白质降解的范围超出细胞内向. 需要进一步的研究来克服挑战,并使临床翻译成为可能.

关键词:
lysosome 是一种溶解体.挑战 挑战 挑战 挑战 挑战展望 展望 展望在进步方面取得了进展.蛋白质向性降解的向性降解

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