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在结直肠癌中,TNF-α缺乏是NK细胞功能障碍的基础

Silvia Ruggeri1, Beatrice Pizzitola1, Mattia Laffranchi1,2

  • 1Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

Oncoimmunology
|February 26, 2026
PubMed
概括

结肠直肠癌 (CRC) 通过减少其频率和功能,损害了自然杀手 (NK) 细胞的免疫力. 由CRC血加剧的TNF-α信号传递的缺陷是驱动这种抑制的关键机制.

关键词:
具有天生的免疫力.在 NK 细胞中,NK 细胞是 NK 细胞.这就是TNF-α.结肠直肠癌是什么意思细胞因子信号传递.

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