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开发和评估复合心声谱评分,用于预测狗的肺高血压严重程度
Wei-Tao Chang1,2, Laín García-Guasch3,4, I-Ping Chan5,6
1Cardiorespiratory Service, National Taiwan University Veterinary Hospital, National Taiwan University, Taipei, Taiwan.
一个新的心声回声计分有助于估计肺高血压 (PH) 在狗,当三回的峰值速度是不可用的. 这种验证的PH评分准确地预测PH严重程度,有助于临床决策.
科学领域:
- 兽医心脏病学 兽医心脏病学
- 诊断成像 诊断成像 诊断成像
- 肺高血压是什么意思 肺高血压
背景情况:
- 三回峰速度 (pTRV) 是估计狗肺动脉静脉压的标准.
- pTRV并不总是可获得的,需要使用替代方法来评估肺高血压 (PH).
- 心声学发现可以表明PH的概率,但在反映严重程度方面有所不同.
研究的目的:
- 开发一个复合的心声回声学得分,用于预测狗的pTRV.
- 为了确定分数的切断值来分层PH严重程度.
- 评估得分与pTRV的相关性及其可靠性.
主要方法:
- 一个多中心的回顾性研究,涉及118名客户拥有的狗,具有可识别的三腹吐.
- 对心声回声学发现的分类,分为6个结构和流量相关的变量.
- 对于可变权重的回归分析,截止分数的ROC曲线,以及预测性表现和可靠性的评估.
主要成果:
- 开发了一个25分加权的PH评分,包括RV壁加厚,RV扩张,RA扩大,肺动脉扩大,心室间隔膜平坦化和RV外流中缩.
- 在没有严重左心房扩张的狗中,得分达到89%的正确分层 (AUC,0.95).
- 推值为3和9的预测pTRV分别为≥3.4m/s和≥4.3m/s,具有强烈的相关性 (rs=0.88) 和优异的内部/间评级协议 (ICC>0.95).
结论:
- 开发的PH评分是评估狗的PH的宝贵补充工具.
- 该得分显示出高预测性表现,特别是在没有严重左心房扩大的情况下.
- 这种工具可以帮助非侵入性地评估犬病患者的肺高血压严重程度.
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